Polypeptide application field
From：
NAMICROBIO CO.,LTD Date：08-02 417 Belong to：Industry Trends
Medical field
The original polypeptide drugs are generally polypeptide hormones. Now the development of polypeptide drugs has been widely used in many fields. The application of polypeptide drugs mainly lies in the following aspects:
1. Cytokine mimetic peptide
Screening cytokine mimetic peptides from peptide library by using known cytokine receptors has become a research hotspot at home and abroad in recent years. Simulated peptides of various growth factors such as human erythropoietin, human thrombopoietin, human growth hormone, human nerve growth factor and interleukin have been screened abroad. The amino acid sequence of these simulated peptides is different from that of their corresponding cytokines, but they have cytokine activity and small molecular weight. These cytokine mimetic peptides are in preclinical or clinical research stage
2. Antibacterial active peptide
When insects are stimulated by the external environment, they produce a large number of cationic peptides with antibacterial activity. More than 100 kinds of antibacterial peptides have been screened. Experiments in vivo and in vitro have confirmed that multiple antibacterial peptides not only have strong bactericidal ability, but also kill tumor cells. For example, the antibacterial peptide D screened from silkworm shows a good application prospect and can be produced by genetic engineering technology. There are also many active peptides in snake venom. A small peptide of 13 amino acids was isolated from snake venom, which has bactericidal ability to G + and G-bacteria
3. Polypeptides for cardiovascular diseases
Many herbal medicines can reduce blood pressure, blood lipid and hemolytic thrombus. They can be used not only as drugs, but also as health food. However, its application is greatly limited because its functional components are uncertain. It has been found that many effective components are small molecular peptides. For example, the active peptides processed and separated from soybeans by Chinese scientists can be directly absorbed through the small intestine, which can prevent thrombosis, hypertension and hyperlipidemia, delay aging and improve the body's anti-tumor ability. Many small peptides for cardiovascular diseases were also isolated from ginseng, tea, Ginkgo biloba and other plants
4. Other small medicinal peptides
In addition to the great progress in the above aspects, small peptide drugs have also made some progress in many other fields. For example, Stiernberg et al. Found that a synthetic peptide (TP508) peptide can promote the regeneration of wound blood vessels and accelerate the healing of deep skin wounds. Pfister et al. Found that a small peptide can prevent alkali from damaging the infiltration of inflammatory cells in the cornea and inhibit the inflammatory response. Carron et al. Confirmed that the two synthetic peptides screened by him could inhibit bone resorption by osteoclasts
5. Diagnostic polypeptide
Polypeptide is mainly used as antigen in diagnostic reagents to detect antibodies against microorganisms such as viruses, cells, mycoplasma and spirochetes and parasites such as cysticercosis and Trypanosoma. Polypeptide antigen has stronger specificity than natural microorganism or parasite protein antigen and is easy to prepare. Therefore, the false negative rate and background reaction of the assembled detection reagent are very low, Easy for clinical application. The antibody detection kit with polypeptide antigen includes: A, B, C, g or HGV, HIV, human cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, Trypanosoma, Lyme disease and rheumatoid. Most of the peptide antigens used are obtained from the analysis and screening of the natural proteins of the corresponding pathogenic body, and some are new small peptides screened from the peptide library
Cosmetics
With the continuous improvement of people's living standards, the market demand for cosmetics is constantly improving, and functional cosmetics are also highly respected. Bioactive polypeptide compounds have the advantages of high bioactivity, easy absorption, safety and non toxicity. Their physiological and biological effects of beauty, skin care and anti-aging have also been gradually applied to beauty cosmetics
At present, the bioactive peptides widely used in beauty, skin care and cosmetics are mainly functional peptides with small molecular weightAnd most of these peptides are prepared by chemical synthesis
1. Copper peptide
The discovery of efficacy in the field of beauty and skin care can be traced back to 1973, American scholar Loren & middot; Picat accidentally discovered that copper peptide has a very significant effect in treating wounds and repairing skin injuries. Since then, the school of medicine of Tulane University in New Orleans has conducted clinical demonstration and concluded that copper peptide can improve human skin aging and restore its original elasticity
2. Acetylhexapeptide-3
Acetyl HEXAPEPTIDE-3, i.e. botulinum like peptide, is the most widely used peptide in beauty polypeptide materials at present. In terms of efficacy, acetyl HEXAPEPTIDE-3 has the same effect of smoothing skin fine lines as type A botulinum toxin, but acetyl HEXAPEPTIDE-3 has high economy in use cost
3. Palmitoyl pentapeptide-3
Palmitoyl pentapeptide-3 is a bioactive polypeptide obtained by chemical synthesis of collagen fragments and palmitic acid. This substance combines the chemical properties of collagen and palmitic acid. When added to cosmetics, it can effectively promote the combination of collagen and glucosamine in skin fiber cells, so as to tighten the skin. At the same time, the application of palmitoyl pentapeptide-3 can balance the complexion and enhance the gloss and transparency of the skin through moisturizing and moisturizing
4. Acetyltetrapeptide-5
Acetyltetrapeptide-5 is also named as eye silk peptide and eye bag removing active peptide in commercial use. As the name suggests, acetyltetrapeptide-5 can reduce eye bags and remove dark circles in beauty and skin care cosmetics. Therefore, it is often added to various eye care products
In addition, there are some new functional beauty peptides, such as progeline new peptide, acyl tetrapeptide-9, tetrapeptide-30 (proline lysine glutamate lysine), syn hycansyn hycan, a new tripeptide syn hycan, and so on.
The original polypeptide drugs are generally polypeptide hormones. Now the development of polypeptide drugs has been widely used in many fields. The application of polypeptide drugs mainly lies in the following aspects:
1. Cytokine mimetic peptide
Screening cytokine mimetic peptides from peptide library by using known cytokine receptors has become a research hotspot at home and abroad in recent years. Simulated peptides of various growth factors such as human erythropoietin, human thrombopoietin, human growth hormone, human nerve growth factor and interleukin have been screened abroad. The amino acid sequence of these simulated peptides is different from that of their corresponding cytokines, but they have cytokine activity and small molecular weight. These cytokine mimetic peptides are in preclinical or clinical research stage
2. Antibacterial active peptide
When insects are stimulated by the external environment, they produce a large number of cationic peptides with antibacterial activity. More than 100 kinds of antibacterial peptides have been screened. Experiments in vivo and in vitro have confirmed that multiple antibacterial peptides not only have strong bactericidal ability, but also kill tumor cells. For example, the antibacterial peptide D screened from silkworm shows a good application prospect and can be produced by genetic engineering technology. There are also many active peptides in snake venom. A small peptide of 13 amino acids was isolated from snake venom, which has bactericidal ability to G + and G-bacteria
3. Polypeptides for cardiovascular diseases
Many herbal medicines can reduce blood pressure, blood lipid and hemolytic thrombus. They can be used not only as drugs, but also as health food. However, its application is greatly limited because its functional components are uncertain. It has been found that many effective components are small molecular peptides. For example, the active peptides processed and separated from soybeans by Chinese scientists can be directly absorbed through the small intestine, which can prevent thrombosis, hypertension and hyperlipidemia, delay aging and improve the body's anti-tumor ability. Many small peptides for cardiovascular diseases were also isolated from ginseng, tea, Ginkgo biloba and other plants
4. Other small medicinal peptides
In addition to the great progress in the above aspects, small peptide drugs have also made some progress in many other fields. For example, Stiernberg et al. Found that a synthetic peptide (TP508) peptide can promote the regeneration of wound blood vessels and accelerate the healing of deep skin wounds. Pfister et al. Found that a small peptide can prevent alkali from damaging the infiltration of inflammatory cells in the cornea and inhibit the inflammatory response. Carron et al. Confirmed that the two synthetic peptides screened by him could inhibit bone resorption by osteoclasts
5. Diagnostic polypeptide
Polypeptide is mainly used as antigen in diagnostic reagents to detect antibodies against microorganisms such as viruses, cells, mycoplasma and spirochetes and parasites such as cysticercosis and Trypanosoma. Polypeptide antigen has stronger specificity than natural microorganism or parasite protein antigen and is easy to prepare. Therefore, the false negative rate and background reaction of the assembled detection reagent are very low, Easy for clinical application. The antibody detection kit with polypeptide antigen includes: A, B, C, g or HGV, HIV, human cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, Trypanosoma, Lyme disease and rheumatoid. Most of the peptide antigens used are obtained from the analysis and screening of the natural proteins of the corresponding pathogenic body, and some are new small peptides screened from the peptide library
Cosmetics
With the continuous improvement of people's living standards, the market demand for cosmetics is constantly improving, and functional cosmetics are also highly respected. Bioactive polypeptide compounds have the advantages of high bioactivity, easy absorption, safety and non toxicity. Their physiological and biological effects of beauty, skin care and anti-aging have also been gradually applied to beauty cosmetics
At present, the bioactive peptides widely used in beauty, skin care and cosmetics are mainly functional peptides with small molecular weightAnd most of these peptides are prepared by chemical synthesis
1. Copper peptide
The discovery of efficacy in the field of beauty and skin care can be traced back to 1973, American scholar Loren & middot; Picat accidentally discovered that copper peptide has a very significant effect in treating wounds and repairing skin injuries. Since then, the school of medicine of Tulane University in New Orleans has conducted clinical demonstration and concluded that copper peptide can improve human skin aging and restore its original elasticity
2. Acetylhexapeptide-3
Acetyl HEXAPEPTIDE-3, i.e. botulinum like peptide, is the most widely used peptide in beauty polypeptide materials at present. In terms of efficacy, acetyl HEXAPEPTIDE-3 has the same effect of smoothing skin fine lines as type A botulinum toxin, but acetyl HEXAPEPTIDE-3 has high economy in use cost
3. Palmitoyl pentapeptide-3
Palmitoyl pentapeptide-3 is a bioactive polypeptide obtained by chemical synthesis of collagen fragments and palmitic acid. This substance combines the chemical properties of collagen and palmitic acid. When added to cosmetics, it can effectively promote the combination of collagen and glucosamine in skin fiber cells, so as to tighten the skin. At the same time, the application of palmitoyl pentapeptide-3 can balance the complexion and enhance the gloss and transparency of the skin through moisturizing and moisturizing
4. Acetyltetrapeptide-5
Acetyltetrapeptide-5 is also named as eye silk peptide and eye bag removing active peptide in commercial use. As the name suggests, acetyltetrapeptide-5 can reduce eye bags and remove dark circles in beauty and skin care cosmetics. Therefore, it is often added to various eye care products
In addition, there are some new functional beauty peptides, such as progeline new peptide, acyl tetrapeptide-9, tetrapeptide-30 (proline lysine glutamate lysine), syn hycansyn hycan, a new tripeptide syn hycan, and so on.
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